2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Na+/K+ ATPase

Na+/K+ ATPase

Sodium potassium pump

Na+/K+ ATPase

Related Products

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Na+/K+ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na+/K+ ATPase is an emerging cancer target that merits further investigation.

The constant activity of the Na+/K+-ATPase (NKA, or Na+ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.

Na+/K+ ATPase Related Products (54):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N1446
    Oleic acid
    		Activator 99.97%
    Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.
    Oleic acid
  • HY-B0542
    Ouabain Octahydrate
    		Inhibitor 99.96%
    Ouabain Octahydrate is an inhibitor of Na+/K+-ATPase, used for the treatment of congestive heart failure.
    Ouabain Octahydrate
  • HY-N1446B
    Sodium oleate
    		Activator ≥98.0%
    Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium. Sodium oleate is a Na+/K+ ATPase activator.
    Sodium oleate
  • HY-N0877
    Bufalin
    		Inhibitor 99.86%
    Bufalin is an active component isolated from Chan Su, acts as a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively. Anti-cancer activity.
    Bufalin
  • HY-N0039
    Ginsenoside Rb1
    		Inhibitor 98.75%
    Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .
    Ginsenoside Rb1
  • HY-116196
    17-HETE
    		Inhibitor
    17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy.
    17-HETE
  • HY-W754708
    Ouabagenin
    		Inhibitor
    Ouabagenin is a naturally occurring LXR ligand with LXR selective agonist activity. Ouabagenin acts as an EC 3.6.3.9 (Na(+)/K(+)- transport ATPase) inhibitor.
    Ouabagenin
  • HY-116444A
    16-HETE
    		Inhibitor
    16-HETE is arachidonic acid metabolite through subterminal hydroxylation by cytochrome P-450. 16-HETE exhibits vasodilatory and PMN inhibitory effects and serves as biomarker for early stages of non-alcoholic fatty liver disease.
    16-HETE
  • HY-B1357
    Digitoxin
    		99.36%
    Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .
    Digitoxin
  • HY-15718A
    Istaroxime hydrochloride
    		Inhibitor 99.32%
    Istaroxime hydrochloride is a Na+/K+-ATPase inhibitor (IC50=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
    Istaroxime hydrochloride
  • HY-B0401
    Tolbutamide
    		Inhibitor 99.96%
    Tolbutamide is an orally active KATP inhibitor. Tolbutamide inhibits cell proliferation, stimulates exocytosis of glucagon and reduces fetal lethality of mice. Tolbutamide can be used in the research of diabete.
    Tolbutamide
  • HY-N0143
    Phlorizin
    		Inhibitor 99.82%
    Phlorizin (Floridzin) is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.
    Phlorizin
  • HY-13719
    Oleandrin
    		Inhibitor 99.93%
    Oleandrin (PBI-05204) inhibits the Na+, K+-ATPase activity with an IC50 of 620 nM.
    Oleandrin
  • HY-12283
    Rostafuroxin
    		Antagonist 98.00%
    Rostafuroxin (PST 2238), a digitoxigenin derivative, is an orally active and potent Na+,K+-ATPase (ATP1A1) antognist. Rostafuroxin binds specifically to the ATP1A1 extracellular domain and blocks respiratory syncytial virus (RSV)-triggered EGFR Tyr845 phosphorylation. Rostafuroxin has antihypertensive and anti-RSV activity.
    Rostafuroxin
  • HY-A0154
    Deslanoside
    		Inhibitor 99.79%
    Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .
    Deslanoside
  • HY-114252
    Strophanthidin
    		Inhibitor
    Strophanthidin is a naturally available cardiac glycoside. Strophanthidin 0.1 and 1 nmol/L increases and 1~100 µmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal. Strophanthidin increases both diastolic and systolic intracellular Ca2+ concentration.
    Strophanthidin
  • HY-Y0413
    Biacetyl monoxime
    		Inhibitor ≥98.0%
    Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca2+ release.
    Biacetyl monoxime
  • HY-B0137
    Prilocaine
    		Inhibitor 99.87%
    Prilocaine, an amino amide, is a Na, K-ATPase inhibitor. Prilocaine has neurotoxic effects.
    Prilocaine
  • HY-N1446S1
    Oleic acid-d2
    		Activator ≥98.0%
    Oleic acid-d2) is the deuterium labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].
    Oleic acid-d<sub>2</sub>
  • HY-N8441
    Neriifolin
    		Inhibitor 99.43%
    Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[2.
    Neriifolin